DAY 1. Tuesday, 2017-03-21 – MITOEAGLE Conference

08:30h – Registration and signature of attendance.
08:45h – Pablo Garcia-Roves (ES) Welcome: Introduction of COST-MITOEAGLE and Barcelona meeting to all participants

A1 » Connecting mitochondrial physiology – global perspectives and case studies

Chair: Kathrin Renner-Sattler (DE)
09:15h – Erich Gnaiger (AT) Quality first: a paradigm shift in mt-respiratory control towards global connection.
09:45h – Paul Coen (USA) To bring MITOEAGLE and MoTrPAC together.
10:15h – General discussion
10:20h – Werner Koopman (NL) Standardized quantification of mitochondrial morphology and function in living patient fibroblasts using microscopy.
10:40h – Roberto Scatena, Patrizia Bottoni (IT) Mitochondria and cancer stem cells in hepatocarcinoma. An illustrative example of a tangled methodological approach.
10:55h – Rob Wüst (NL) Mitochondrial Complex I function in heart failure: different angles to analyze mitochondrial function.
11:10-11:40h – COFFEE BREAK

A2 » Connecting data on cardiac and skeletal muscle mitochondria

Chair: Terje Larsen (NO)
11:40h – Andrew Murray (UK) Metabolic adaptation to high altitude in Himalayan Sherpas.
12:10h – Hervé Dubouchaud (FR) Effects of different fatty acids on skeletal muscle mitochondrial function.

12:25h – Michal Nemec (SK) Functional state of mitochondria in patients with preclinical and early stage neurodegenerative disease”
12:40h – Arild Rustan (NO) Metabolic studies in human skeletal muscle cells.
12:55h – Ellen Aasum (NO) Mitochondrial function in the diabetic heart – effect of an acute fat-load.
13:10h – Marko Vendelin (EE) VDACs open in the heart mitochondria.
13:25h – General discussion
13:40-15:00h – LUNCH

A3 » Connecting data on adipocyte mitochondria

Chair: Jan Nedergaard (SE)
15:00h – Irina Shabalina (SE) Control of UCP1 activity in brown fat mitochondria.
15:30h – Tobias Fromme (DE) Source depot and dietary status influence oxidative phosphorylation capacity in permeabilized mature adipocytes.
15:45h – Manuela Sanchez-Feutrie (ES) RAP250 deficiency protects from obesity, and enhances mitochondrial metabolism in adipose depots.
16:00h – Marc Claret (ES) Mitochondrial performance and central regulation of energy balance.
16:15h – Lisa Chakrabarti (UK) Mitochondrial lipid and proteomics comparative studies in mammalian ageing.
16:30-17:00h – COFFEE BREAK

A4 » Connecting data on cultured cells and blood cells

Chair: Magdalena Labieniec-Watala (PL)
17:00h – Nicoleta Moisoi (UK) Models of Parkinson’s with focus on cell lines.
17:30h – Claus Desler (DK) Mitochondrial mediated genomic instability in aging with focus on cell lines.
17:15h – Elisa Calabria (IT) Age and frailty related changes in PBMCs mitochondrial function and whole body physiology.
18:00h – Maria Monsalve (ES) Mitochondrial biogenesis in PMBC: potential biomarkers.
18:15h – Slawomir Michalak (PL) Mitochondrial respiration in intact peripheral blood mononuclear cells in patients with extrapyramidal syndromes.
18:30h – Clair Hartmann (DE) Mitochondrial respiration of peripheral blood mononuclear cells in an experimental porcine brain injury model.
18:45h – Karolina Siewiera (PL) The effect of metformin on blood platelet bioenergetics and platelet function.

DAY 2. Wednesday, 2017-03-22 – Working Groups (WG)

B1 » Joint WG meeting

Chair: Elisa Calabria – Italy
09:00h – WG1 Presentation of tasks and current status.
09:30h – WG2 Presentation of tasks and current status.
10:00h – WG3 Presentation of tasks and current status.
10:30h – WG4 Presentation of tasks and current status.
11:00-11:30h COFFEE BREAK

B2 » Specific WG presentations (5+5 min)

Chair: Pablo Garcia-Roves (ES)
11:30h – Erich Gnaiger (AT) Current proposal about ‘New terminology’ on SUIT protocols and coupling/pathway control states (WG1).
11:45h – Marina Makrecka-Kuka (LT) Fatty acid oxidation evaluation in mitochondria (WG1).
12:00h – Paul Coen (USA) and Pablo Garcia-Roves (ES) Technical perspective of high-resolution respirometry in permeabilized skinned muscle fibers: humans and animal models (WG2).
12:30h – Odeta Arandarcikaite (LT) Age-related responses of brain mitochondria to ischemic insult (WG3).
12:45h – Ondrej Sobotka (CZ) The effect of 24 weeks of high-fat and high-cholesterol diet on rat liver mitochondria (WG3).
13:00h – Mario Ost (DE) Multivariate biomarkers of age-dependent sarcopenia: A blood based bioenergetics & cytokine profiling approach (WG4).
13:15h – Natasha Kopitar-Jerala (SI) Mitochondrial ROS and inflammation (WG4).
13:30–14:30h – LUNCH

B3 » Specific WG meetings

14:30-17:00h
WG1 – Room TBA
WG2 – Room TBA
WG3 – Room TBA
WG4 – Room TBA
17:00-17:30h COFFEE BREAK

B4 » Joint WG meeting – conclusions and future WG actions

17:30h – WG1: Towards a preprint publication on terminology in mitochondrial respiratory physiology.
17:50h – WG2: Fatty acid oxidation evaluation in mitochondria
18:10h – WG3:
18:40h – WG4:

DAY 3. Thursday, 2017-03-23 – Management Committee (MC)

C1 » MC meeting

09:00h – Management Committee Meeting
11:00-11:30h – COFFEE BREAK
13:00h – End