Irina Milisav is a full Professor of Biochemistry and Molecular Biology employed at University of Ljubljana at Faculty of Medicine, Institute of Pathophysiology as Research Associate and Faculty of Health Science on a teaching post. She is lecturing undergraduate and graduate students at the Faculty of Health Sciences. She also teaches some students at University of Ljubljana Interdisciplinary Doctoral Programme in Biomedicine. She has supervised 3 PhD students, 1 MSc student, 4 junior research students (3 of them were awarded Prešeren research prize). Her main research interests are adaptive cellular stress responses, apoptosis triggering, aging induced stress & nutrition and the role of antioxidants and ROS in stress responses and is is extending her research interests in Clinical nutrition on the role of antioxidants in disease prevention and specific pathologies. She is a Slovenian representative on the European network of researchers on reactive oxygen species, COST CA15136 EUROCAROTEN, and CA16112 Personalized Nutrition in aging society actions, a section editor of the journal Archives of Medical Sciences and is listed in Marquis Who’sWho in the World since 2013.
1. Group description
The laboratory for Cell Physiology and Toxinology at University of Ljubljana, Faculty of Medicine, Institute of Pathophysiology consists of Magnetic Resonance Centre, Neurophysiology group and Molecular studies group.
2. TREATMENT project
ESR11 will analyse the interferences of antipsychotic drugs on hepatocyte adaptive responses that determine loss of function, compromised survival and induction of fibrosis in order to determine how the drugs alter the adaptive responses of liver cells and how they impact hepatocyte functionality and their capacity to survive in response to stressors. The ESR will test the acute effect of antipsychotic drug treatment on primary hepatocytes and liver slices. Mice treated with antipsychotic drugs will be used to investigate how the putative loss in hepatocyte functionality impacts on the induction of steatosis, fibrosis and steatohepatitis and evaluation of increased liver sensitivity to damage. Links will be established between the short-term impairment of hepatic functionality following drug administration with long-term enhanced sensitivity to liver stressors likely to be associated with increased liver fat accumulation and development of fibrosis.
3. Current funding
- Slovenian Research Agency (research core funding No. P3-0019).
4. Group members
- Blaž Banič – Postdoctoral fellow
- Izak Muller – PhD student
7. Selected publications
- Nipič Damjan, Pirc, Aleš, Banič Blaž., Šuput, Dušan, Milisav, Irina. (2010). Preapoptotic cell stress response of primary hepatocytes. Hepatology 51, 2140-2151.
- Banič, Blaž, Nipič, Damijan, Šuput, Dušan, Milisav, Irina (2011). DMSO modulates the pathway of apoptosis triggering. Cell. Mol. Biol. Lett. 16, 328-341.
- Milisav, Irina, Poljšak, Borut, Šuput, Dušan (2012). Adaptive response, evidence of cross-resistance and its potential clinical use. Int J Mol Sci. 13, 10771-806. doi:10.3390/ijms130910771.
- Poljšak, Borut, Milisav, Irina (2014). Oxidized forms of dietary antioxidants: friends or foes?. Trends in food science & technology, 39, 156-166.
- Milisav, Irina, Poljšak, Borut, Ribarič, Samo (2017). Reduced risk of apoptosis: mechanisms of stress responses. Apoptosis, 22, 265-283.